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Synergetic Tumor Probes for Facilitating Therapeutic Delivery by Combined-Functionalized Peptide Ligands
journal contribution
posted on 2020-03-05, 17:39 authored by Xiangqian Jia, Mingmei Guo, Qiuju Han, Yuwei Tian, Yafei Yuan, Zihua Wang, Yixia Qian, Weizhi WangBoth targeting and
penetrating ability are the key characteristics
for tissue probing and precise delivery. To construct an efficient
nano probing and delivery system toward human epidermal growth factor
receptor 2 (HER2) positive cancer, we established a nano liposomal
system functionalized with a newly screened HER2 targeting peptide
(HP2, YDLKEPEH) and the cell-penetrating peptide TAT simultaneously.
Compared with the monofunctionalized liposomal probes, the dual-functional
ones demonstrated a synergetic effect in cell uptake, drug delivery,
and in vivo imaging. The improved efficacy of the synergetic system
provides a prospective strategy for cancer diagnosis and therapy.
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synergetic effectdrug deliveryvivo imagingsynergetic systemHPdelivery systemCombined-Functionalized Peptide LigandsSynergetic Tumor ProbesYDLKEPEHcell-penetrating peptide TATcell uptakedual-functional onesmonofunctionalized liposomal probesepidermal growth factor receptor 2cancer diagnosisnano liposomal system functionalizedHER 2Facilitating Therapeutic Delivery
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