nl6b00054_si_001.pdf (16.8 MB)
Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility
journal contribution
posted on 2016-04-12, 16:18 authored by Christina
J. Newcomb, Shantanu Sur, Sungsoo S. Lee, Jeong Min Yu, Yan Zhou, Malcolm L. Snead, Samuel I. StuppThe nanostructures
of self-assembling biomaterials have been previously designed to tune
the release of growth factors in order to optimize biological repair
and regeneration. We report here on the discovery that weakly cohesive
peptide nanostructures in terms of intermolecular hydrogen bonding,
when combined with low concentrations of osteogenic growth factor,
enhance both BMP-2 and Wnt mediated signaling in myoblasts and bone
marrow stromal cells, respectively. Conversely, analogous nanostructures
with enhanced levels of internal hydrogen bonding and cohesion lead
to an overall reduction in BMP-2 signaling. We propose that the mechanism
for enhanced growth factor signaling by the nanostructures is related
to their ability to increase diffusion within membrane lipid rafts.
The phenomenon reported here could lead to new nanomedicine strategies
to mediate growth factor signaling for translational targets.