jo500478u_si_001.pdf (1.21 MB)
Sulfone-Mediated Syntheses of Crocetin Derivatives: Regioselectivity of Highly Functionalized Building Blocks
journal contribution
posted on 2014-05-16, 00:00 authored by Eun-Taek Oh, Young-Hun Kim, Jingquan Jin, Liang Su, Jung-Ah Seo, Sangho KooNew C5 sulfone building
blocks containing a masked polar
end group have been devised for the efficient synthesis of carotenoids
with polar termini. Chemoselectivity or the regiochemical issue of
the highly functionalized units has been carefully addressed depending
on the soft or hard nature of electrophiles. These building blocks
have been successfully applied to the syntheses of crocetin derivatives,
crocetin dial and the novel crocetin dinitrile.