Structure-Modified Germatranes for Pd-Catalyzed Biaryl Synthesis
2018-09-04T00:00:00Z (GMT) by
Germanium, a member of 14th group that falls between Si and Sn, has remained considerably ignored as a nucleophile for a long time. Compared with other forms of Ge-containing nucleophiles, germatranes are structure-defined, easily accessible, and stabilized nucleophilic fragments, but they fail to meet the need of high reactivity and facile introducing to organics. Herein, we report a modified structure of germatranes, whose cross-coupling reactivity is greatly improved. The structure can be easily constructed from inexpensive industrial GeO<sub>2</sub>, and corresponding <b><i>Ge</i></b>-Cl and <b><i>Ge</i></b>-H can also be obtained after facile transformations. Moreover, Ar-<b><i>Ge</i></b> can be effectively synthesized either from Grignard reagents or Pd-catalyzed germylation of aryl halides.