ic7b02668_si_001.pdf (1.53 MB)
Strategies toward the Enhanced Permeability and Retention Effect by Increasing the Molecular Weight of Arene Ruthenium Metallaassemblies
journal contribution
posted on 2017-12-22, 13:22 authored by Vidya Mannancherril, Bruno TherrienThe
enhanced permeability and retention (EPR) effect is an attractive
avenue to target tumors: The size of the drug is the key to accumulating
predominantly in tumors. Therefore, to increase the molecular weight
of arene ruthenium metallaassemblies, several strategies can be adopted,
and we present here our first step in the design of larger and heavier
discrete arene ruthenium metallaassemblies to reach an EPR-size dimension.