mz0c00030_si_001.avi (1.58 MB)
Straightforward Access to Glycosylated, Acid Sensitive Nanogels by Host–Guest Interactions with Sugar-Modified Pillar[5]arenes
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posted on 2020-03-24, 17:36 authored by Peng Wei, Justyna A. Czaplewska, Limin Wang, Stephanie Schubert, Johannes C. Brendel, Ulrich S. SchubertThe
introduction of specific targeting units to polymer nanogels usually
requires tedious chemical modifications, which limits flexibility
in the design of combinatorial approaches. Here, we present a straightforward
and versatile method to reversibly introduce various carbohydrate-based
targeting units to a pH-sensitive nanogel via host–guest interactions.
Glucose-, mannose-, or fructose-modified pillar[5]arenes can adaptably
and conveniently be introduced to the surface of the nanogel. Binding
studies between these nanogels and the lectin Concanavalin A revealed
a high selectivity and strong interaction with only the mannose-modified
nanogels. With the addition of other pillar[5]arenes, the interaction
can be influenced proving a dynamic exchange of the targeting units.
In comparison with common covalent modifications of polymer nanostructures,
the presented combination of straightforward precipitation polymerization
and supramolecular interactions promises convenient access to adaptable
nanostructures for high-throughput screening of targeted delivery
systems.
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chemical modificationslimits flexibilitycovalent modificationslectin Concanavalinmannose-modified nanogelspolymer nanostructureshigh-throughput screeningprecipitation polymerizationpH-sensitive nanogelBinding studiescombinatorial approachespolymer nanogelspillarStraightforward Accesssupramolecular interactionsdelivery systems
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