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Stimulus-Responsive Imprinted Polymer-Based Potentiometric Sensor for Reversible Detection of Neutral Phenols
journal contribution
posted on 2020-03-06, 15:41 authored by Longbin Qi, Rongning Liang, Wei QinNowadays, polymeric
membrane potentiometric sensors based on the
molecularly imprinted polymers (MIPs) have been successfully developed
for detection of various organic and biological species. However,
it is difficult for these sensors to perform reversible detection
of the targets due to the high affinities of the MIPs toward the targets.
In this work, we propose a novel method for fully reversible potentiometric
detection of neutral phenols based on the stimulus-responsive MIP
as the selective receptor. Since such smart receptor can switch its
recognition abilities according to the external environmental stimuli,
the MIP binding sites in the polymeric membrane can be regenerated
via the stimulus after each measurement. Thus, potentiometric reversible
detection of the target can be achieved. As a proof of concept, the
pH-responsive MIP is used as the selective receptor, which can be
synthesized by using 4-vinylphenylboronic acid as the functional monomer.
The boronate-affinity MIP can covalently bind with a cis-diol containing compound to form a five- or six-membered cyclic
ester in a weakly alkaline aqueous solution, while the produced ester
dissociates when the surrounding pH is changed to acidic. By using
catechol as a model, the proposed smart sensor exhibits a significantly
improved reversibility compared to the conventional MIP-based sensor.
We believed that the stimulus-responsive MIP-based sensing strategy
could provide an appealing way to design reversible MIP-based electrochemical
and optical sensors.
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membrane potentiometric sensorsstimulus-responsive MIPreceptor4- vinylphenylboronic acidboronate-affinity MIPStimulus-Responsive Imprinted Polymer-Based Potentiometric Sensorpotentiometric detectionMIPscovalently bindMIP binding sitesstimulus-responsive MIP-basedsix-membered cyclic estersensor exhibitsMIP-based electrochemicalMIP-based sensorReversible Detectionrecognition abilitiesnovel methodpH-responsive MIPNeutral Phenols
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