op9b00381_si_001.pdf (1.98 MB)
Stereospecific Amination of Mesylated Cyclobutanol in Continuous Flow
journal contribution
posted on 2019-11-13, 21:07 authored by Matthieu Tissot, Jérôme Jacq, Patrick PasauWe report an amination of mesylated cyclobutanol enabled
by a multistep
continuous flow process. The flow sequence involved an azidation followed
by a Staudinger reduction which avoids the handling and isolation
of a hazardous alkyl azide compound. The process is stereospecific
with the azidation step proceeding to complete stereochemical inversion.