ol102246d_si_001.pdf (2.77 MB)
Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation
journal contribution
posted on 2010-11-19, 00:00 authored by Chunliang Lu, Qing Xiao, Paul E. FloreancigSpirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit. The products are well-suited for diversification to prepare libraries.