ol5b01787_si_001.pdf (3.91 MB)
Stereoselective Synthesis of 3‑Carboxy-4,5-dihydropyrroles via an Intramolecular Iminium Ion Cyclization Reaction
journal contribution
posted on 2015-08-07, 00:00 authored by Jinbao Xiang, Hongxiang Xie, Zhuo Li, Qun Dang, Xu BaiAn
efficient and practical method has been developed for the synthesis
of trans-4,5-disubstituted 3-carboxy-4,5-dihydropyrroles
via an intramolecular iminium ion cyclization reaction of readily
accessible Baylis–Hillman derivatives and aldehydes in moderate
to high yield. These new dihydropyrroles could be easily converted
to pyrroles or pyrrolidines.