Stereoselective Synthesis and Structural Correction of the Naturally Occurring Lactone Stagonolide G
2010-12-17T00:00:00Z (GMT) by
A convergent synthesis of the structure proposed for the naturally occurring lactone stagonolide G is described. All three stereocenters were created with the aid of asymmetric Brown allylations. The lactone ring was built by means of a ring-closing metathesis (RCM). The synthetic and the natural compound differed in their spectral properties. A new structure is now proposed for stagonolide G and demonstrated by means of a chemical transformation.