Stereoselective Synthesis and Absolute Configuration of the C1′−C25′ Fragment of Symbiodinolide
2009-09-04T00:00:00Z (GMT) by
Stereoselective synthesis of the C1′−C25′ fragment of symbiodinolide, which was obtained as a degraded product from symbiodinolide by alkaline hydrolysis, has been accomplished. The synthetic route features Kotsuki coupling and Julia−Kocienski olefination in the introduction of the side chains. This enantio- and stereoselective synthesis has established the absolute configuration of the C1′−C25′ fragment.