Stereoselective Preparation of Functionalized Acyclic Alkenylmagnesium Reagents Using i-PrMgCl·LiCl
2004-11-11T00:00:00Z (GMT) by
Acyclic functionalized alkenyl iodides are converted with high stereoselectivity to the corresponding functionalized alkenylmagnesium derivatives by the reaction with i-PrMgCl·LiCl between −40 and −20 °C. Functional groups such as a nitrile, chloride, iodide, and ester are readily tolerated. The conversion of an alkenyl iodide bearing a keto group to the corresponding silylated cyanohydrin allows preparation of the corresponding Grignard reagent affording, after acylation and deprotection, unsaturated 1,4-diketones.
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