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Stereoselective Preparation of Functionalized Acyclic Alkenylmagnesium Reagents Using i-PrMgCl·LiCl
journal contribution
posted on 2004-11-11, 00:00 authored by Hongjun Ren, Arkady Krasovskiy, Paul KnochelAcyclic functionalized alkenyl iodides are converted with high stereoselectivity to the corresponding functionalized alkenylmagnesium derivatives
by the reaction with i-PrMgCl·LiCl between −40 and −20 °C. Functional groups such as a nitrile, chloride, iodide, and ester are readily tolerated.
The conversion of an alkenyl iodide bearing a keto group to the corresponding silylated cyanohydrin allows preparation of the corresponding
Grignard reagent affording, after acylation and deprotection, unsaturated 1,4-diketones.