jo302813y_si_001.pdf (791.65 kB)
Stereoselective Approach to the Racemic Oxatetracyclic Core of Platensimycin
journal contribution
posted on 2016-02-19, 17:39 authored by Sakuya Horii, Munefumi Torihata, Tomohiro Nagasawa, Shigefumi KuwaharaA highly stereoselective synthesis of the racemic oxatetracyclic
core of platensimycin has been accomplished from a known bicyclic
epoxy lactone by an 11-step sequence that involves a Diels–Alder
cyclcoaddition to construct its cis-decalenone structural
motif with complete regio- and stereoselectivity and a ring-closing
metathesis to establish its whole carbon framework.