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Specific Interactions of Complementary Mono- and Multivalent Guests with Recognition-Induced Polymersomes
journal contribution
posted on 2002-11-26, 00:00 authored by Raymond J. Thibault, Trent H. Galow, Erik J. Turnberg, Mark Gray, Peter J. Hotchkiss, Vincent M. RotelloWe have explored the interactions of mono- and multivalent guests with Recognition-Induced
Polymersomes (RIPs) formed from complementary random copolymers featuring diamidopyridine and
thymine functionality. Addition of monovalent guests featuring imide functionality to these RIPs induced a
temporary swelling of the vesicles, followed by dissociation of the vesicles due to competitive binding of
the guest. Conversely, multivalent thymine-functionalized nanoparticle guests were rapidly incorporated
into the RIPs, inducing a contraction of RIP diameter over time. These mono- and multivalent interactions
were extremely specific: highly analogous control systems showed no interaction with the RIP structures.
Taken together, these studies demonstrate highly selective molecular “lock and key” control over higher-order assembly and recognition processes.