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Sophalines E–I, Five Quinolizidine-Based Alkaloids with Antiviral Activities against the Hepatitis B Virus from the Seeds of Sophora alopecuroides
journal contribution
posted on 2018-09-11, 17:52 authored by Yu-Bo Zhang, Li Yang, Ding Luo, Neng-Hua Chen, Zhong-Nan Wu, Wen-Cai Ye, Yao-Lan Li, Guo-Cai WangFive novel quinolizidine-based
alkaloids (1–5) were obtained from
the seeds of Sophora alopecuroides L. Compounds 1 and 2 are the first examples
of sparteine-indolizine and matrine-indolizine alkaloids, respectively,
whereas 3 and 4 are epimeric normatrine-julolidine
alkaloids with unusual skeletons. The structures of these compounds
were determined by spectroscopic methods, single-crystal X-ray diffraction,
and electronic circular dichroism analyses. Hypothetical biosynthetic
pathways of 1–5 were proposed. Compound 2 exhibited significant antiviral activity against the hepatitis
B virus.
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Compound 2novel quinolizidine-based alkaloidssingle-crystal X-ray diffractionHepatitis B VirusCompounds 1Quinolizidine-Based AlkaloidsHypothetical biosynthetic pathwaysSophora alopecuroidesSophora alopecuroides LAntiviral Activitiesepimeric normatrine-julolidine alkaloidshepatitis B virusmatrine-indolizine alkaloidsspectroscopic methodsdichroism analyses
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