ol801471f_si_001.pdf (1.29 MB)
Sonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper
journal contribution
posted on 2008-09-04, 00:00 authored by Bruce H. Lipshutz, David W. Chung, Brian RichCross-coupling reactions between lipophilic terminal alkynes and aryl bromides can be catalyzed by ligated Pd, in the absence of copper, in pure water at ambient temperatures. Small amounts of the nonionic amphiphile PTS assist by virtue of nanometer micelles formed spontaneously in an aqueous medium.