Sonochemical Synthesis of Hydrophilic Drug Loaded
Multifunctional Bovine Serum Albumin Nanocapsules

Li, Zhanfeng; Yang, Ting; Lin, Chunming; Li, Quanshun; Liu, Songfeng; Xu, Fengzhi; Wang, Hongyan; Cui, Xuejun

doi:10.1021/acsami.5b05558.s001

am5b05558_si_001.pdf (446.47 kB)

Sonochemical Synthesis of Hydrophilic Drug Loaded Multifunctional Bovine Serum Albumin Nanocapsules

journal contribution

posted on 2015-09-02, 00:00 authored by Zhanfeng Li, Ting Yang, Chunming Lin, Quanshun Li, Songfeng Liu, Fengzhi Xu, Hongyan Wang, Xuejun Cui

A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.