mz9b00576_si_001.pdf (1.37 MB)
Sono-Polymerization of Poly(ethylene glycol)-Based Nanoparticles for Targeted Drug Delivery
journal contribution
posted on 2019-09-19, 12:36 authored by Zhiliang Gao, Haiyan Zhu, Xiaoyu Li, Peiyu Zhang, Muthupandian Ashokkumar, Francesca Cavalieri, Jingcheng Hao, Jiwei CuiEngineering functional nanoparticles
(NPs) with low nonspecific
interactions and a high specific targeting property is highly desired
for improved drug delivery. Herein, we report a targeted poly(ethylene
glycol) (PEG)-based chemotherapy system synthesized via a catalyst-free
sono-polymerization process for drug delivery. The polymerization
process was fast (20 min), and different monomers were able to be
polymerized to form NPs in a one-pot process. Glutathione (GSH)-responsive
platinum prodrugs and fluorescent dyes could be encapsulated in NPs
by amidation formation. Cyclic peptides containing Arg-Gly-Asp (RGD)-modified
PEG-based NPs possessed a much higher cell targeting (∼90%)
than the unmodified PEG-based NPs (∼10%) after a 12 h incubation
with U87 MG cells, which could improve drug delivery efficacy. The
IC50 (50% inhibitory concentration) could also be reduced
more than 50% compared to the nontargeted PEG-based NPs. Importantly,
these PEG-based NPs can be freeze-dried into a powder form and redispersed
in an aqueous solution without aggregation, which may facilitate the
storage and transportation of nanomedicine. This study establishes
a green and efficient method to engineer targeted drug carriers for
drug delivery.