jo4006574_si_001.pdf (5.81 MB)
Solvent-Free Methallylboration of Ketones Accelerated by tert-Alcohols
journal contribution
posted on 2016-02-19, 06:53 authored by Yongda Zhang, Ning Li, Navneet Goyal, Guisheng Li, Heewon Lee, Bruce Z. Lu, Chris H. SenanayakeA solvent-
and metal-free process has been developed for the direct
methallylboration of ketones employing the stable B-methallylborinane 1, which was accelerated by tertiary
alcohols. In the presence of 2.0 equiv of readily available tertiary
alcohols such as tert-amyl alcohol, the methallylation
products were prepared at room temperature in excellent yields. The
salient features of the described process include simple operation,
high efficiency, and mild reaction conditions.