jo8b00737_si_001.pdf (12.17 MB)
Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3‑Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor
journal contribution
posted on 2018-05-16, 00:00 authored by Qiong Yang, Guo-Li Dai, Yu-Ming Yang, Zhuangzhu Luo, Zhen-Yu TangEfficient syntheses
of 3,3-difluorooxindoles and 3-fluorooxindoles
via fluorination of hydrazonoindolin-2-one with Selectfluor are reported.
Under different solvent conditions, this method produced 3,3-difluorooxindoles
and 3-fluorooxindoles selectively. The broad substrate scope and mild
reaction conditions make this transformation a valuable method in
drug discovery and development.