Smart Nanofibers with a Photoresponsive Surface for Controlled Release

A novel photocontrolled “ON−OFF” release system for the α-cyclodextrin-5-fluorouracial (α-CD−5FU) prodrug, based on host−guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated. The nanofibers with a stimuli-responsive surface were electrospun from the block copolymer prepared via controlled radical polymerization, followed by surface modification via “Click Chemistry”, and loading of the prodrug via host−guest interaction.