bc9b00700_si_001.pdf (1.47 MB)
Size-Dependent Photothermal Conversion and Photoluminescence of Theranostic NaNdF4 Nanoparticles under Excitation of Different-Wavelength Lasers
journal contribution
posted on 2019-12-04, 14:51 authored by Lihua Ding, Feng Ren, Zheng Liu, Zhilin Jiang, Baofeng Yun, Qiao Sun, Zhen LiThe narrow absorption and emission bands, long fluorescence
lifetime,
and excellent stability of rare earth nanoparticles (referred to as
RE NPs) make them very attractive for multimodal imaging and therapy
of cancer. Their narrow absorption requires the careful selection
of laser wavelength to achieve the best performance, particularly
for RE NPs simultaneously having photothermal and photoluminescent
properties (e.g., Nd-based nanoparticles), which has not been investigated.
Herein, we prepared a series of different-sized NaNdF4 nanoparticles
(referred to as NNF NPs) (i.e., 4.7, 5.9, 12.8, and 15.6 nm) from
ultrasmall nanoclusters and investigated their in vitro and in vivo size-dependent photothermal conversion
and photoluminescence under irradiation by a 793 nm laser and an 808
nm laser, respectively. We find that all nanoparticles exhibited the
better photothermal conversion performance under the irradiation of
the 808 nm laser than under the 793 nm laser, of which 12.8 nm NNF
NPs showed the best performance, and the temperature of their solution
can be quickly increased from 30 °C to around 60 °C within
10 min under the irradiation of the 808 nm laser with a power intensity
of 0.75 W/cm2. When we used the 793 nm laser to excite
these NNF NPs, we found that all nanoparticles exhibited the stronger
photoluminescence in the second near-infrared window (NIR-II) than
under the excitation by the 808 nm laser, of which 15.6 nm NNF NPs
possessed the strongest NIR-II luminescence. We then modified 12.8
nm NNF NPs with phospholipid carboxyl PEG and functionalized with
RGD for actively targeted imaging of cancer. The NaNdF4@PEG@RGD nanoparticles (referred to as NNF-P-R NPs) have good biocompatibility,
stability, and excellent targeting capability. The in vivo result show that 12.8 nm NNF NPs exhibited better photothermal conversion
performance under the irradiation of the 808 nm laser, and stronger
NIR-II fluorescence under irradiation of the 793 nm laser, which are
consistent with the in vitro result. This work demonstrates
the significance of selection of the proper laser wavelength for maximally
taking advantage of RE nanoparticles for the diagnosis and treatment
of cancer.
History
Usage metrics
Categories
Keywords
12.8 nm NNF NPs793 nm laserNNF NPs808 nm laserlaser wavelengthirradiationphospholipid carboxyl PEGRE NPsvivo result showphotothermal conversion performancevivo size-dependent photothermal conversionNNF-P-RNIR-IIdifferent-sized NaNdF 4 nanoparticlesTheranostic NaNdF 4 NanoparticlesRGD15.6 nm NNF NPsSize-Dependent Photothermal Conversion
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC