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Singlet Oxygen Generation via Two-Photon Excited FRET

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journal contribution
posted on 2004-05-05, 00:00 authored by William R. Dichtel, Jason M. Serin, Carine Edder, Jean M. J. Fréchet, Michael Matuszewski, Loon-Seng Tan, Tymish Y. Ohulchanskyy, Paras N. Prasad
A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

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