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Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms
journal contribution
posted on 2017-01-06, 00:00 authored by Bahaa
G. Mahmoud, Mohamed Khairy, Farouk A. Rashwan, Craig E. BanksTo
overcome the recent outbreaks of hepatotoxicity-related drugs,
a new analytical tool for the continuously determination of these
drugs in human fluids is required. Electrochemical-based analytical
methods offer an effective, rapid, and simple tool for on-site determination
of various organic and inorganic species. However, the design of a
sensitive, selective, stable, and reproducible sensor is still a major
challenge. In the present manuscript, a facile, one-pot hydrothermal
synthesis of bismuth oxide (Bi2O2.33) nanostructures
(nanorods) was developed. These BiO nanorods were cast onto mass disposable
graphite screen-printed electrodes (BiO-SPEs), allowing the ultrasensitive
determination of acetaminophen (APAP) in the presence of its common
interference isoniazid (INH), which are both found in drug samples.
The simultaneous electroanalytical sensing using BiO-SPEs exhibited
strong electrocatalytic activity toward the sensing of APAP and INH
with an enhanced analytical signal (voltammetric peak) over that achievable
at unmodified (bare) SPEs. The electroanalytical sensing of APAP and
INH are possible with accessible linear ranges from 0.5 to 1250 μM
and 5 to 1760 μM with limits of detection (3σ) of 30 nM
and 1.85 μM, respectively. The stability, reproducibility, and
repeatability of BiO-SPE were also investigated. The BiO-SPEs were
evaluated toward the sensing of APAP and INH in human serum, urine,
saliva, and tablet samples. The results presented in this paper demonstrate
that BiO-SPEs sensing platforms provide a potential candidate for
the accurate determination of APAP and INH within human fluids and
pharmaceutical formulations.
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electroanalytical1250 μ MSPEgraphite screen-printed electrodesdrug samplesvoltammetric peak1760 μ MBiO nanorodsSimultaneous Voltammetric Determinationone-pot hydrothermal synthesishepatotoxicity-related drugsBiO-SPEINHtablet samples1.85 μ MHepatotoxicity-Related Drugs30 nMultrasensitive determinationAPAPtoolUtilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemicalmethods offerBi 2 O 2.33electrocatalytic activityfluidbismuth oxideinterference isoniazid
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