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Simplified Isolation Procedure and Interconversion of the Diastereomers of Nepetalactone and Nepetalactol
datasetposted on 24.06.2005 by Ilme Liblikas, Ellen M. Santangelo, Johan Sandell, Peter Baeckström, Mats Svensson, Ulla Jacobsson, C. Rikard Unelius
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Three nepetalactones were isolated from Nepeta racemosa (mussinii) by traditional methods. An improved method was developed to isolate nepetalactones from N. faassénii. An epimerization procedure was used to prepare the fourth 7S-nepetalactone diastereomer. The cis-fused nepetalactols were prepared by reduction of the corresponding nepetalactones, while the trans-fused nepetalactols were unstable and found to undergo ring-opening reactions yielding iridodials. The characterizations and structural assignments by means of NMR agree with quantum chemical density functional calculations.