ol6b00722_si_001.pdf (20.96 MB)
Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones
journal contribution
posted on 2016-04-21, 13:06 authored by Sheng-Ying Hsieh, Jeffrey W. BodeSilicon
amine protocol (SLAP) reagents for photocatalytic cross-coupling
with aldehydes and ketones to form N-unprotected
piperazines have been developed. This blue light promoted process
tolerates a wide range of heteroaromatic, aromatic, and aliphatic
aldehydes and structurally and stereochemically complex SLAP reagents.
It provides a tin-free alternative to SnAP (tin amine protocol) reagents
for the synthesis of substituted piperazines.