ol017058i_si_002.cif (35.17 kB)
Short Total Synthesis of (+)-Madindolines A and B
dataset
posted on 2002-01-30, 00:00 authored by Tomoyasu Hirose, Toshiaki Sunazuka, Tatsuya Shirahata, Daisuke Yamamoto, Yoshihiro Harigaya, Isao Kuwajima, Satoshi ŌmuraA short and efficient total synthesis of (+)-madindolines A (1) and B (2), potent and selective inhibitors of interleukin 6, has been achieved.
The synthesis features a key chelation-controlled 1,4-diastereoselective acylation to generate the quaternary carbon and an intramolecular
acylation of allylsilane to build up the cyclopentene unit.