np6b01100_si_001.pdf (8.13 MB)
Sesqui- and Diterpenoids from the Radix of Curcuma aromatica
journal contribution
posted on 2017-12-13, 17:53 authored by Shengjuan Dong, Baocai Li, Weifeng Dai, Dong Wang, Yi Qin, Mi ZhangEight new sesquiterpenoids (1–8), two new diterpenoids (9 and 10), and
17 known sesqui- and diterpenoids (11–27) were isolated from the radix of Curcuma aromatica. Among these compounds, 1 is an unprecedented guaiane
with unique cyclopropane and furan functionalities, and 9 is the first atisane diterpenoid isolated from a Curcuma species. Their 2D and 3D structures were established using HRESIMS
and spectroscopic methods, including ECD and IECD data. The antioxidant
activities of compounds 1–27 were
evaluated based on their ability to protect PC12 cells against H2O2-induced damage, with 1, 2, 5–8, 11, 12, 14, 16, 18, and 19 exhibiting notable antioxidant effects on oxidative injury induced
by H2O2.