Self-Duplicating Amplification in a Dynamic Combinatorial Library

2008-02-13T00:00:00Z (GMT) by Shengguang Xu Nicolas Giuseppone
A dynamic combinatorial library has been designed to produce a set of constituents among which one is able to self-complementarily direct its duplication. The overall molecular distribution in the library evolves along both kinetic and thermodynamic biases, leading to the amplification of the species that reproduces most efficiently and to the depletion of the other competitors.