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Self-Sorting Microscale Compartmentalized Block Copolypeptide Hydrogels
journal contribution
posted on 2019-09-17, 15:52 authored by Yintao Sun, Laurent A. Bentolila, Timothy J. DemingMulticomponent interpenetrating network
hydrogels possessing enhanced
mechanical stiffness compared to their individual components were
prepared via physical mixing of diblock copolypeptides that assemble
by either hydrophobic association or polyion complexation in aqueous
media. Optical microscopy analysis of fluorescent-probe-labeled multicomponent
hydrogels revealed that the diblock copolypeptide components rapidly
and spontaneously self-sort to form distinct hydrogel networks that
interpenetrate at micron length scales. These materials represent
a class of microscale compartmentalized hydrogels composed of degradable,
cell-compatible components, which possess rapid self-healing properties
and independently tunable domains for downstream applications in biology
and additive manufacturing.
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hydrogel networkspolyion complexationSelf-Sorting Microscale Compartmentalized Block Copolypeptide Hydrogels Multicomponent interpenetrating network hydrogelsfluorescent-probe-labeled multicomponent hydrogelsdiblock copolypeptide componentsself-healing propertiescell-compatible componentsadditive manufacturingmicroscale compartmentalized hydrogelsOptical microscopy analysismicron length scalesdiblock copolypeptidestunable domains
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