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Selective Ion Exchange Governed by the Irving–Williams Series in K2Zn3[Fe(CN)6]2 Nanoparticles: Toward a Designer Prodrug for Wilson’s Disease
journal contribution
posted on 2015-02-16, 00:00 authored by Murthi S. Kandanapitiye, Fan Jennifer Wang, Benjamin Valley, Chamila Gunathilake, Mietek Jaroniec, Songping D. HuangThe
principle of the Irving–Williams series is applied to the design
of a novel prodrug based on K2Zn3[Fe(CN)6]2 nanoparticles (ZnPB NPs) for Wilson’s
disease (WD), a rare but fatal genetic disorder characterized by the
accumulation of excess copper in the liver and other vital organs.
The predetermined ion-exchange reaction rather than chelation between
ZnPB NPs and copper ions leads to high selectivity of such NPs for
copper in the presence of the other endogenous metal ions. Furthermore,
ZnPB NPs are highly water-dispersible and noncytotoxic and can be
readily internalized by cells to target intracellular copper ions
for selective copper detoxification, suggesting their potential application
as a new-generation treatment for WD.