ao9b00700_si_001.pdf (2.02 MB)
Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors
journal contribution
posted on 2020-03-06, 09:30 authored by J. Johannes Eksteen, Dominik Ausbacher, Terje Vasskog, Øystein Rekdal, John S. M. SvendsenShort histidine-rich peptides could
serve as novel activatable
vectors for delivering cytotoxic payloads to tumor and neovasculature
cells. This explorative study reports preliminary results showing
that zinc ions, which are found in elevated levels at neovasculature
sites, can trigger the intracellular delivery of a short antimicrobial
peptide when conjugated to a histidine-rich peptide through a disulfide
bond. The importance of exofacial thiols in the mode of action of
these disulfide-linked conjugates is also shown.
History
Usage metrics
Categories
Keywords
explorative study reportsneovasculature cellsThiolated CargoHistidine-Rich Peptideshistidine-rich peptidedisulfide-linked conjugatesdisulfide bondcytotoxic payloadshistidine-rich peptidesantimicrobial peptideNeovasculature Cellszinc ionsexofacial thiolsintracellular deliveryneovasculature sitesnovel activatable vectorsSelective Intracellular Delivery
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC