op0c00158_si_001.pdf (1.33 MB)
Selective DIBAL‑H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo Lab
journal contribution
posted on 2020-05-21, 16:42 authored by Nick Uhlig, Andrew Martins, Detian GaoHerein
we report a selective DIBAL-H-mediated reduction of a heterocyclic
diester to the corresponding monoaldehyde using continuous flow chemistry.
The use of continuous flow enabled operation at lower temperatures
and better control of the reaction time, thereby allowing for a significant
increase in reaction selectivity and yield compared with batch conditions.
The reaction’s development as a continuous flow process and
its scale-up from laboratory gram scale to multikilogram scale are
discussed, including design of experiments studies to probe the optimal
reaction window.