Room-Temperature Ligand-Free Pd/C-Catalyzed C–S Bond Formation: Synthesis of 2‑Substituted Benzothiazoles

The synthesis of 2-substituted benzothiazoles has been achieved via cyclization of o-iodothiobenzanilide derivatives using Pd/C as the catalyst at room temperature. The protocol is ligand-free, additive-free, and high-yielding and involves very mild conditions.