Room-Temperature Ligand-Free Pd/C-Catalyzed C–S Bond Formation: Synthesis of 2‑Substituted Benzothiazoles
journal contributionposted on 20.06.2014 by Yannan Cheng, Qian Peng, Weigang Fan, Pixu Li
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The synthesis of 2-substituted benzothiazoles has been achieved via cyclization of o-iodothiobenzanilide derivatives using Pd/C as the catalyst at room temperature. The protocol is ligand-free, additive-free, and high-yielding and involves very mild conditions.