ol0270327_si_001.pdf (377.96 kB)
Ring-Opening Metathesis Phase-Trafficking (ROMpt) Synthesis: Multistep Synthesis on Soluble ROM Supports
journal contribution
posted on 2002-12-10, 00:00 authored by Andrew M. Harned, Shubhasish Mukherjee, Daniel L. Flynn, Paul R. HansonThe use of ring-opening metathesis (ROM) oligomers as soluble supports for a multistep reaction sequence is described. A Mitsunobu reaction
followed by an in situ ROMP-mediated phase-trafficking purification is utilized to generate soluble ROM oligomers that are isolated via precipitation
with methanol. Once formed, the ROM oligomers serve as soluble supports for further solution-phase reactions, including a ring-closing
metathesis. After each step, the support-bound products are isolated by precipitation with a suitable solvent.