ol7b01863_si_001.pdf (1.64 MB)
Rhodomollanol A, a Highly Oxygenated Diterpenoid with a 5/7/5/5 Tetracyclic Carbon Skeleton from the Leaves of Rhododendron molle
journal contribution
posted on 2017-07-13, 12:23 authored by Junfei Zhou, Guanqun Zhan, Hanqi Zhang, Qihua Zhang, Ying Li, Yongbo Xue, Guangmin YaoA novel
diterpenoid with an unprecedented carbon skeleton, rhodomollanol
A (1), and a new grayanane diterpenoid, rhodomollein
XXXI (2), were isolated from the leaves of Rhododendron
molle. Their structures were elucidated using comprehensive
spectroscopic methods and single-crystal X-ray diffraction. Compound 1 possesses a unique cis/trans/trans/cis/cis-fused 3/5/7/5/5/5 hexacyclic ring system featuring a rare 7-oxabicyclo[4.2.1]nonane
core decorated with three cyclopentane units. The plausible biosynthetic
pathway for 1 was proposed. Compound 1 exhibited
moderate PTP1B inhibitory activity.