jo8b00086_si_001.pdf (11.22 MB)
Rhodium(III)-Catalyzed C(sp3)–H Bond Aminocarbonylation with Isocyanates
journal contribution
posted on 2018-03-16, 00:00 authored by Huaiqing Zhao, Xi Zhou, Bo Li, Xiufen Liu, Ningxin Guo, Zhengliang Lu, Shoufeng WangRh(III)-catalyzed C(sp3)–H bond aminocarbonylation
of 8-methylquinolines and isocyanates has been realized under mild
conditions. This approach is applicable to different aryl and alkyl
isocyanates, leading to the synthesis of various α-quinolinyl
amide compounds in moderate to excellent yields. A plausible mechanism
for this transformation is proposed according to the experimental
results obtained.