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Rhodium(III)-Catalyzed C(sp3)–H Bond Aminocarbonylation with Isocyanates

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journal contribution
posted on 2018-03-16, 00:00 authored by Huaiqing Zhao, Xi Zhou, Bo Li, Xiufen Liu, Ningxin Guo, Zhengliang Lu, Shoufeng Wang
Rh­(III)-catalyzed C­(sp3)–H bond aminocarbonylation of 8-methylquinolines and isocyanates has been realized under mild conditions. This approach is applicable to different aryl and alkyl isocyanates, leading to the synthesis of various α-quinolinyl amide compounds in moderate to excellent yields. A plausible mechanism for this transformation is proposed according to the experimental results obtained.

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