jo2024224_si_001.pdf (1.07 MB)
Rhodium-Catalyzed Asymmetric Arylation of N-(tert-Butanesulfinyl)imines with Sodium Tetraarylborates
journal contribution
posted on 2012-01-20, 00:00 authored by Leleti Rajender Reddy, Aditya P. Gupta, Eric Villhauer, Yugang LiuA diastereoselective rhodium-catalyzed arylation of N-(tert-butanesulfinyl)imines with sodium
tetraarylborates
is described. This method is general for constructing various chiral
α-branched amines and 2-substituted pyrrolidines with high diastereoselectivity.
A practical asymmetric approach to access chiral amines has been developed
involving the use of air-stable Rh catalysts and reagents and in the
absence of an external ligand.