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Rhodium-Catalyzed Asymmetric Arylation of N-(tert-Butanesulfinyl)imines with Sodium Tetraarylborates

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journal contribution
posted on 2012-01-20, 00:00 authored by Leleti Rajender Reddy, Aditya P. Gupta, Eric Villhauer, Yugang Liu
A diastereoselective rhodium-catalyzed arylation of N-(tert-butanesulfinyl)­imines with sodium tetraarylborates is described. This method is general for constructing various chiral α-branched amines and 2-substituted pyrrolidines with high diastereoselectivity. A practical asymmetric approach to access chiral amines has been developed involving the use of air-stable Rh catalysts and reagents and in the absence of an external ligand.

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