Rh(I)-Catalyzed Alkylation of <i>ortho</i>-C–H Bonds in Aromatic Amides with Maleimides

An alkylation of C–H bonds with maleimides by a rhodium-catalyzed reaction of aromatic amides containing an 8-aminoquinoline moiety as the directing group is reported. Various <i>N</i>-substituents in the maleimide, including methyl, ethyl, cyclohexyl, benzyl, and phenyl groups and even H, are applicable to the reaction. The reaction is highly regioselective at the less hindered <i>ortho</i>-C–H bond when <i>meta</i>-substituted aromatic amides are used as substrates.