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Rh(III)-Catalyzed Enaminone-Directed C–H Coupling with α‑Diazo-α-phosphonoacetate for Reactivity Discovery: Fluoride-Mediated Dephosphonation for C–C Coupling Reactions

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journal contribution
posted on 18.06.2018 by Chao Song, Chen Yang, Hua Zeng, Wenjing Zhang, Shan Guo, Jin Zhu
Rh­(III)-catalyzed enaminone-directed C–H coupling with α-diazo-α-phosphonoacetate has been used for the identification of fluoride-mediated dephosphonation C–C coupling reactivity for the synthesis of 4-hydroxy-1-naphthoates. Intermolecular C–C coupling of α-phosphonoacetate and benzaldehyde for (E)-selective α,β-unsaturated ester synthesis has also been achieved.