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Resolution of Omeprazole Using Coupled Preferential Crystallization: Efficient Separation of a Nonracemizable Conglomerate Salt under Near-Equilibrium Conditions
journal contribution
posted on 2016-02-19, 05:34 authored by Jason E. Hein, Blessing Huynh Cao, Maarten
W. van der Meijden, Michel Leeman, Richard M. KelloggA facile
and efficient resolution of omeprazole as the monopotassium
salt diethanol solvate using coupled preferential crystallization
has been developed. This approach uses small perturbations in solution-phase
concentration to control the competing process of selective crystal
growth while suppressing unwanted primary nucleation. The result is
a selective crystallization technique that replaces the traditional
batch-type isolation with a continuous process amenable to scale,
which provides easy access to enantiopure conglomerate crystals.