jo0c00284_si_001.pdf (8.74 MB)
Relayed Proton Brake in N‑Pyridyl-2-iso-propylaniline Derivative: Two Brakes with One Proton
journal contribution
posted on 2020-03-12, 12:11 authored by Gaku Furukawa, Takeshi Shirai, Yuki Homma, Elsa Caytan, Nicolas Vanthuyne, Daniel Farran, Christian Roussel, Osamu KitagawaThe
addition of methanesulfonic acid to N-(2,6-dimethylpyridin-4-yl)-N-methyl-2-iso-propylaniline led to the selective
protonation of the pyridine nitrogen atom, resulting in a significant
deceleration of the rotation rates around both N-pyridyl
and N-(i-Pr)phenyl bonds through
a relayed brake mechanism.