mt9b01010_si_001.pdf (1.78 MB)
Regulation of Biomolecular-Motor-Driven Cargo Transport by Microtubules under Mechanical Stress
journal contribution
posted on 2020-03-05, 16:34 authored by Syeda
Rubaiya Nasrin, Tanjina Afrin, Arif Md. Rashedul Kabir, Daisuke Inoue, Takayuki Torisawa, Kazuhiro Oiwa, Kazuki Sada, Akira KakugoMechanical
stress on cells has profound influences on biological
processes, such as cell shape regulation, the formation of tissue
patterns, and development. Recently, mechanosensing properties of
the microtubule, an important cytoskeletal component, have drawn attention.
In this work, we studied cargo transport by dynein, a microtubule-associated
motor protein, along microtubules deformed under mechanical stress.
We reveal that the microtubule deformation took place as a response
to the applied stress and that the deformation of microtubules facilitated
the transport of dynein-driven quantum dots. This finding will provide
opportunities to explore the role of microtubules as molecular mechanotransducers
in cellular processes.
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