ic5b00450_si_001.pdf (1.48 MB)
Regioselectivity of the C‑Metalation of 6‑Furylpurine: Importance of Directing Effects
journal contribution
posted on 2015-05-04, 00:00 authored by Indranil Sinha, Alexander Hepp, Birgitta Schirmer, Jutta Kösters, Johannes Neugebauer, Jens MüllerWe report the C-metalation of 6-furylpurine
with Pt2+, Pd2+, and Hg2+. The ligand
binds the metal ions in a bidentate fashion, involving the N7 purine
atom and one of the furyl carbon atoms. The regioselectivity is determined
by the metal ion. Pt2+ and Pd2+ coordinate the
furyl moiety in its β position and Hg2+ in its electronically
preferred α position.