jo7b02920_si_001.pdf (9.72 MB)
Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol
journal contribution
posted on 2017-12-19, 00:00 authored by Ren-Jin Tang, Thierry Milcent, Benoit CrousseRegioselective halogenation
of arenes and heterocycles with N-halosuccinimides
in fluorinated alcohols is disclosed.
Under mild condition reactions, a wide diversity of halogenated arenes
are obtained in good yields with high regioselectivity. Additionally,
the versatility of the method is demonstrated by the development of
one-pot sequential halogenation and halogenation-Suzuki cross-coupling
reactions.