ja505794u_si_001.pdf (4.42 MB)
Regio- and Chemoselective Intermolecular Hydroamination of Allyl Imines for the Synthesis of 1,2-Diamines
journal contribution
posted on 2014-08-13, 00:00 authored by Andrew
R. Ickes, Seth C. Ensign, Anil K. Gupta, Kami L. HullThe
synthesis of 1,2-diamines via a Rh-catalyzed intermolecular
hydroamination of N-allyl imines with cyclic amines
is presented. Coordinating groups proximal to the olefin bind to the
catalyst and promote the transformation. The reaction affords 1,2-diamines
in very good yields and is functional-group-tolerant and highly diastereoselective.