Reduction of Δ2-Isoxazolines to β-Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent
2008-11-21T00:00:00Z (GMT) by
A detailed study of a procedure for the selective reduction of Δ2-isoxazolines to the corresponding β-hydroxy ketones is reported. The use of iron and ammonium chloride as the reducing agent in the presence of water results in a facile and chemoselective protocol for the preparation of β-hydroxy ketones, including the conjugated β-hydroxy ketones.
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