Ready Synthetic Access to Enantiopure Allylic α(F)-Branched Fluoroalkenes
journal contributionposted on 19.02.2016 by Florent Larnaud, Julien Malassis, Emmanuel Pfund, Bruno Linclau, Thierry Lequeux
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Convenient access to homochiral fluoroalkenes is described via a Julia–Kocienski olefination reaction. The required homochiral fluorosulfone is synthesized by a Mitsunobu reaction from readily available enantiopure secondary alcohols.